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Hydrochloric Acid → [4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2-Thiazolamine, 4-(4-methoxyphenyl)-5-(3-pyridinyl)- | HCID 3024894 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | [4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine hydrochloride | HCID 13518884 | 80% |
反応手順
[4-(4-Methoxyphenyl)-5-(3-pyridyl)-1,3-thiazol-2-yl]amine (200 mg) was dissolved in 1% methanol solution of hydrogen chloride (3.2 mL), and the solvent was evaporated. The crude crystalline was recrystallized from methanol-ethyl acetate to give the title compound (180 mg, yield 80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06620825B1 |
| 出典データセット | uspto-grants-2003_09 |
| ORD ID | ord-a3a863d09d644c3eaf32f139827f41ad |
| 出典メモ | uspto-grants-2003_09 |