Water → N-(4-bromo-2-methylphenyl)butanamide
反応式
[C:1]([NH:6][C:7]1[C:8]([CH3:13])=[CH:9][CH:10]=[CH:11][CH:12]=1)(=[O:5])[CH2:2][CH2:3][CH3:4].[Br:14]Br.O>C(O)(=O)C>[Br:14][C:10]1[CH:11]=[CH:12][C:7]([NH:6][C:1](=[O:5])[CH2:2][CH2:3][CH3:4])=[C:8]([CH3:13])[CH:9]=1参加物
5
実験手順
30 g of N-butyryl-o-toluidine and 150 g of glacial acetic acid were initially charged at 30° C. A solution of 33 g of bromine in 66 g of glacial acetic acid was added with stirring and then stirring was continued at from 25 to 30° C. for 1 hour. 300 ml of water were then added to the reaction mixture which, after continued stirring for a short time, was filtered, the crystals were washed with water and dried under reduced pressure. 42.5 g (98% yield) of N-(4-bromo-2-methylphenyl)butanamide were obtained in 99.4% purity.
後処理
- stirringstirring
- stirringafter continued stirring for a short time
- filtrationwas filtered
- washthe crystals were washed with water
- customdried under reduced pressure
出典と根拠
- ORDレコード
- ord-cb27b065bf404f3fb13abd026073b5c2
- 出典データセット
- uspto-grants-2003_09
- 特許番号
- US06620962B2
反応ノート
読み込み中…