Methanol → 2,3,5,6-Tetrafluorobenzaldehyde

HRID 1168615

反応式

HRID 1168615 の反応式
[F:1][C:2]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[C:6]([F:12])[C:3]=1[C:4]#N.C[OH:14].O>[Ni].C(O)(=O)C>[F:1][C:2]1[C:9]([F:10])=[CH:8][C:7]([F:11])=[C:6]([F:12])[C:3]=1[CH:4]=[O:14]

参加物

6

反応物 3

HCID 887MethanolHCID 962WaterHCID 2975462,3,5,6-Tetrafluorobenzonitrile

生成物 1

HCID 6013312,3,5,6-Tetrafluorobenzaldehyde

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 176Acetic Acid溶媒

反応条件

温度
60 °C

実験手順

Into a 500 ml-volume glass-made reactor equipped with a condenser tube, 5.00 g of 2,3,5,6-tetrafluorobenzonitrile, 51.00 g of methanol, 52.00 g of water, 45.00 g of acetic acid and 0.50 g of sponge nickel were charged. After purging the vapor phase moiety with hydrogen gas, the mixed solution was stirred at 60° C. under atmospheric pressure while continuously supplying hydrogen. As the time passed, the reaction solution was sampled and analyzed by means of a gas chromatograph. As a result, it was confirmed that 2,3,5,6-tetrafluorobenzyl alcohol was produced together with 2,3,5,6-tetrafluorobenzaldehyde. The yields in the reaction solution are shown in the table below.

後処理

  1. customInto a 500 ml-volume glass-made reactor equipped with a condenser tube
  2. customAfter purging the vapor phase moiety with hydrogen gas
  3. aliquotthe reaction solution was sampled

出典と根拠

ORDレコード
ord-2843fd65e4114ad7b0200ec157170cfe
出典データセット
uspto-grants-2003_09
特許番号
US06624336B1

関連ノート

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