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2-Benzofurancarboxylic acid, 5-nitro-, ethyl ester → Ethyl 5-aminobenzofuran-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Benzofurancarboxylic acid, 5-nitro-, ethyl ester | HCID 1382954 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | Ethyl 5-aminobenzofuran-2-carboxylate | HCID 9837138 | — |
反応手順
A solution of 2.3 g of ethyl 5-nitrobenzofuran-2-carboxylate in 60 ml of methanol is hydrogenated in the presence of Raney nickel. The catalyst is filtered off and the solution is concentrated. After customary working up, ethyl 5-aminobenzofuran-2-carboxylate, Rf 0.1 (dichloromethane/ethanol 9.5:0.5) obtained; hydrochloride m.p. 246°-248°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723614 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-fb1ddf8127a44d35bcac2a8bffbfe5d1 |
| 出典メモ | uspto-grants-1998_03 |