Water → 6-bromo-3-(4-methylphenyl)-2H-1-benzopyran

HRID 1169351ノート

反応式

HRID 1169351 の反応式
[Br-].[Br:2][C:3]1[CH:4]=[CH:5][C:6]([O:29][CH2:30][C:31]([C:33]2[CH:38]=[CH:37][C:36]([CH3:39])=[CH:35][CH:34]=2)=O)=[C:7]([CH:28]=1)[CH2:8][P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[O-]CC.[Na+].O>C(O)C>[Br:2][C:3]1[CH:4]=[CH:5][C:6]2[O:29][CH2:30][C:31]([C:33]3[CH:34]=[CH:35][C:36]([CH3:39])=[CH:37][CH:38]=3)=[CH:8][C:7]=2[CH:28]=1

参加物

5

反応物 3

HCID 962WaterHCID 2723922Sodium ethoxideHCID 86759182[5-Bromo-2-[2-(4-methylphenyl)-2-oxoethoxy]benzyl](triphenyl)phosphonium bromide

生成物 1

HCID 229901326-bromo-3-(4-methylphenyl)-2H-1-benzopyran収率 85.6%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

Into a suspension of [5-bromo-2-[2-(4-methylphenyl)-2-oxoethoxy]benzyl](triphenyl)phosphonium bromide (5.53 g) in ethanol (20 ml) was added at room temperature a 20% solution of sodium ethoxide in ethanol (2.85 g), and the resulting mixture was stirred for 24 hours. After addition of water (15 ml) to the reaction mixture, a solid material was collected by filtration and was washed with water. The solid material were purified by recrystallization (ethanol) to obtain 6-bromo-3-(4-methylphenyl)-2H-1-benzopyran (2.16 g) as colorless crystals.

後処理

  1. filtrationa solid material was collected by filtration
  2. washwas washed with water
  3. customThe solid material were purified by recrystallization (ethanol)

出典と根拠

ORDレコード
ord-bed4e0e270044b65b9c1efcc1d4c8796
出典データセット
uspto-grants-2003_09
特許番号
US06627651B1

反応ノート

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