Sulfuric Acid → HCID 87551501、化合物

HRID 1169548

反応式

HRID 1169548 の反応式
[CH:1]1[C:23]2=[C:24]3[C:4]4[C:5]([CH:17]=[CH:18][C:19]3=[C:20](S([O-])(=O)=O)[CH:21]=[C:22]2[OH:25])=[C:6](S([O-])(=O)=O)[CH:7]=[C:8](S([O-])(=O)=O)[C:3]=4[CH:2]=1.[Na+:30].[Na+].[Na+].[S:33](=O)(=[O:36])([OH:35])[OH:34]>>[OH:25][C:22]1[CH:21]=[CH:20][C:19]2[C:24]3=[C:4]4[C:5]([CH:6]=[CH:7][CH:8]=[C:3]4[C:2]([S:33]([O-:36])(=[O:35])=[O:34])=[CH:1][C:23]=13)=[CH:17][CH:18]=2.[Na+:30]

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 61388Pyranine

生成物 1

HCID 87551501HCID 87551501、化合物収率 10%

実験手順

The synthesis of mono-CysMA is given in Scheme 1. Reaction of HPTS with 30% sulfuric acid at 150° C. for 20 min gave sodium 3-hydroxypyrene-5-sulfonate 1 in 10% yield. Acetylation of 1 followed by chlorination of 2 gave intermediate 3, which is analogous to HPTS-Cl but with only one sulfonyl chloride. The polymerizable group was attached via the cysteic acid moiety and reacted with 3 to give compound 4. Chlorosulfonation of 4 was achieved without affecting the polymerizable group and after purification on polystyrene beads gave mono-CysMA in 50% yield over two steps. The dye was characterized by 1H NMR, HPLC, and MS.

後処理

  1. customThe synthesis of mono-CysMA

出典と根拠

ORDレコード
ord-5ea673af3dfc433898ef8a9a9355e419
出典データセット
uspto-grants-2010_11
特許番号
US07824918B2

関連ノート

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