5-Iodosalicylic acid → Tert-butyl 4-(2-hydroxy-5-iodobenzoyl)piperazine-1-carboxylate

反応式

ClC1C=CC(C([N:8]2[CH2:13][CH2:12][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:10][CH2:9]2)=O)=CC=1C#N.[OH:25][C:26]1[CH:34]=[CH:33][C:32]([I:35])=[CH:31][C:27]=1[C:28]([OH:30])=O>>[OH:25][C:26]1[CH:34]=[CH:33][C:32]([I:35])=[CH:31][C:27]=1[C:28]([N:8]1[CH2:9][CH2:10][N:11]([C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])[CH2:12][CH2:13]1)=[O:30]

参加物

反応物 2

HCID 83885-Iodosalicylic acid

HCID 68766029Tert-butyl 4-(4-chloro-3-cyanobenzoyl)piperazine-1-carboxylate

生成物 1

HCID 31121968Tert-butyl 4-(2-hydroxy-5-iodobenzoyl)piperazine-1-carboxylate

実験手順

Performed identical to tert-butyl 4-(4-chloro-3-cyanobenzoyl)piperazine-1-carboxylate in Example 1 except 2-hydroxy-5-iodobenzoic acid was used in place of 3-cyano-4-chlorobenzoic acid.

出典と根拠

ORDレコード: ord-d0384ed933044b5ca5f5f86bcfb212fd
出典データセット: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07825120B2

反応ノート

読み込み中…