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4-Pyridinecarboxaldehyde → (s)-5-Methyl-1-pyrid-4-ylmethyl-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| 反応物 | 4-Aminophenyl trifluoromethyl sulphone | HCID 136315 | — |
| 反応物 | (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-hydroxypropanoic acid | HCID 6541433 | — |
| 生成物 | (s)-5-Methyl-1-pyrid-4-ylmethyl-3-(4-trifluoromethanesulfonylphenyl)imidazolidine-2,4-dione trifluoroacetate | HCID 10346809 | — |
反応手順
The compound is prepared from 0.025 mmol of resin, 0.075 mmol of N-Fmoc-L-Ala(OH), 0.125 mmol of 4-pyridinecarboxaldehyde and 0.0625 mmol of 4-(trifluoromethanesulfonyl)aniline, in the same way as in Example 1. After purification by preparative LC-MS, 5.6 mg of expected product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07825115B2 |
| 出典データセット | uspto-grants-2010_11 |
| ORD ID | ord-a741a58c5de34633bffd80cb578aba68 |
| 出典メモ | uspto-grants-2010_11 |