ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Potassium Carbonate → 1-(2-Chloropyrid-4-ylmethyl)-5,5-dimethyl-3-(4-trifluoromethylsulfanylphenyl)imidazolidine-2,4-dione

HRID 1169653
ノート
印刷プレビュー

反応式

HRID 1169653 の反応式
[CH3:1][C:2]([NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][C:14]([S:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=1)=[O:9])([CH3:6])[C:3]([O-:5])=O.C([O-])([O-])=O.[K+].[K+].[Cl:28][C:29]1[CH:34]=[C:33]([CH2:35]Cl)[CH:32]=[CH:31][N:30]=1>CN(C=O)C>[Cl:28][C:29]1[CH:34]=[C:33]([CH2:35][N:7]2[C:2]([CH3:1])([CH3:6])[C:3](=[O:5])[N:10]([C:11]3[CH:16]=[CH:15][C:14]([S:17][C:18]([F:21])([F:20])[F:19])=[CH:13][CH:12]=3)[C:8]2=[O:9])[CH:32]=[CH:31][N:30]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 111265732-Chloro-4-(chloromethyl)pyridineHCID 86595327HCID 86595327、化合物

生成物 1

HCID 545814241-(2-Chloropyrid-4-ylmethyl)-5,5-dimethyl-3-(4-trifluoromethylsulfanylphenyl)imidazolidine-2,4-dione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

5,5-Dimethyl-3-(4-trifluoromethylsulfanylphenyl)imidazolidine-2,4-dione 3 (1 g, 3.29 mmol) is dissolved in 10 ml of DMF, 1.36 g of K2CO3 (3 eq, 9.87 mmol) and 909 mg of 2-chloro-4-chloromethylpyridine (3.95 mmol, 1.2 eq) are added, and the mixture is refluxed for 20 hours. The solvent is removed under vacuum and the residue is dissolved in CH2Cl2 and treated three times with active charcoal. After removing the solvent, the product 1-(2-chloropyrid-4-ylmethyl)-5,5-dimethyl-3-(4-trifluoromethylsulfanylphenyl)imidazolidine-2,4-dione is obtained (3.2 g; 56%).

後処理

  1. temperaturethe mixture is refluxed for 20 hours
  2. customThe solvent is removed under vacuum
  3. dissolutionthe residue is dissolved in CH2Cl2
  4. additiontreated three times with active charcoal
  5. customAfter removing the solvent

出典と根拠

ORDレコード
ord-e3d3da865ed64fdc80a9e9989428a10d
出典データセット
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07825115B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート