Triethylamine → (1-Methyl-1H-1,2,4-triazol-5-yl)methyl methanesulfonate
反応式
[CH3:1][N:2]1[C:6]([CH2:7][OH:8])=[N:5][CH:4]=[N:3]1.C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>ClCCl>[CH3:16][S:17]([O:8][CH2:7][C:6]1[N:2]([CH3:1])[N:3]=[CH:4][N:5]=1)(=[O:19])=[O:18]参加物
5
実験手順
To a solution of (1-methyl-1H-1,2,4-triazol-5-yl)methanol (53 mg, 0.47 mmol) in 2 mL of dichloromethane was added triethylamine (0.13 mL, 0.94 mmol), followed by methanesulfonyl chloride (0.044 mL, 0.56 mmol). The mixture was stirred at room temperature for 3 hours, then partitioned between EtOAc and water. The organic layer was washed with saturated NaHCO3 solution and brine, dried over Na2SO4, filtered, and concentrated in vacuo to give the title product. ESI+MS: 192.2 [M+H]+.
後処理
- custompartitioned between EtOAc and water
- washThe organic layer was washed with saturated NaHCO3 solution and brine
- dry with materialdried over Na2SO4
- filtrationfiltered
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-3be42d30239c49a0a84b2c38aaeb997a
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07825131B2
反応ノート
読み込み中…