L-Leucinol → (S)-2-(2-chloro-5-thiophen-3-yl-pyrimidine-4-ylamino)-4-methyl-pentan-1-ol

反応式

[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5](I)=[CH:4][N:3]=1.[NH2:10][C@H:11]([CH2:16][OH:17])[CH2:12][CH:13]([CH3:15])[CH3:14].[S:18]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19]1>>[Cl:1][C:2]1[N:7]=[C:6]([NH:10][C@@H:11]([CH2:12][CH:13]([CH3:15])[CH3:14])[CH2:16][OH:17])[C:5]([C:20]2[CH:21]=[CH:22][S:18][CH:19]=2)=[CH:4][N:3]=1

参加物

反応物 3

HCID 111307L-Leucinol

HCID 2634382,4-Dichloro-5-iodopyrimidine

HCID 581760Thiophene-3-boronic acid

生成物 1

HCID 58985746(S)-2-(2-chloro-5-thiophen-3-yl-pyrimidine-4-ylamino)-4-methyl-pentan-1-ol

実験手順

Preparation according to procedures 2 and 3 with the use of 2,4-dichloro-5-iodopyrimidine, L-leucinol (Aldrich) and thiophen-3-boronic acid (Aldrich).

後処理

customPreparation

出典と根拠

ORDレコード: ord-f90ae3f480174176bb7fd6fd7bb25163
出典データセット: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07825128B2

反応ノート

読み込み中…