化工社化工社 化学情報印刷レポート · 研究参考用
Benzaldehyde → 2-Benzylidene-but-3-ynenitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzaldehyde | HCID 240 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Malononitrile | HCID 8010 | — |
| 触媒 | Piperidine | HCID 8082 | — |
| 生成物 | 2-Benzylidene-but-3-ynenitrile | HCID 86030656 | — |
反応手順
To a solution of benzaldehyde (2 g; 18.9 mmol) and malononitrile (1.37 g; 20.7 mmol) in ethanol (40 ml) was added 5 drops of piperidine and the mixture was heated at reflux overnight. The reaction was cooled, evaporated then purified by flash column chromatography eluting with 1:9 ethyl acetate/hexane and the product containing fractions combined and evaporated to give 930 mg of 2-benzylidene-but-3-yne nitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07825140B2 |
| 出典データセット | uspto-grants-2010_11 |
| ORD ID | ord-5a2abd7f645947b0b3ee9eb00a0bdf66 |
| 出典メモ | uspto-grants-2010_11 |