Bromine → 2-Amino-3-bromo-5-methylbenzoic acid

HRID 1169977ノート

反応式

HRID 1169977 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[Br:12]Br>C(O)(=O)C>[NH2:1][C:2]1[C:10]([Br:12])=[CH:9][C:8]([CH3:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

4

反応物 2

HCID 24408BromineHCID 762552-Amino-5-methylbenzoic acid

生成物 1

HCID 27744002-Amino-3-bromo-5-methylbenzoic acid収率 85.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 2-amino-5-methylbenzoic acid (25.0 g, 170 mmol) in acetic acid (250 ml) was added bromine (10 ml, 195 mmol) and the reaction mixture was stirred at room temperature for 2 h. The mixture was filtered and the solid material was washed with water and cyclohexane and dried to give the title compound (33.4 g).

後処理

  1. filtrationThe mixture was filtered
  2. washthe solid material was washed with water and cyclohexane
  3. customdried

出典と根拠

ORDレコード
ord-5679cf46e3e942f5892e452b3773d499
出典データセット
uspto-grants-2010_11
特許番号
US07825149B2

反応ノート

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