1-Phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime → 2-Amino-1-phenyl-2-pyridin-2-ylethanol

HRID 1170392ノート

反応式

HRID 1170392 の反応式
[C:1]1([C:7](=[O:17])[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)=[N:9]O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H][H]>C(O)C.[Pt]=O>[NH2:9][CH:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=1)[CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[OH:17]

参加物

5

反応物 2

HCID 1364068481-Phenyl-2-pyridin-2-ylethane-1,2-dione 2-oximeHCID 178418361HCID 178418361、化合物

生成物 1

HCID 675240462-Amino-1-phenyl-2-pyridin-2-ylethanol

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

25.3 g of 1-phenyl-2-pyridin-2-ylethane-1,2-dione 2-oxime were dissolved in 300 ml of ethanol and, after addition of 1.0 g of platinum oxide, hydrogenated under atmospheric pressure until no further hydrogen was taken up. Filtration and concentration of the solution resulted in 21.6 g of 2-amino-1-phenyl-2-pyridin-2-ylethanol as mixture of 2 diastereomers.

後処理

  1. filtrationFiltration and concentration of the solution
  2. customresulted in 21.6 g of 2-amino-1-phenyl-2-pyridin-2-ylethanol as mixture of 2 diastereomers

出典と根拠

ORDレコード
ord-a6abacd96d98429f9e5311bd0448a4f8
出典データセット
uspto-grants-2010_11
特許番号
US07825264B2

反応ノート

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