1,3-Bis(aminomethyl)cyclohexane → (3-Aminomethyl-cyclohexylmethyl)-[2-(2-naphthalen-1-yl-vinyl)-quinazolin-4-yl]-amine

HRID 1171042

反応式

HRID 1171042 の反応式
Cl[CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH:12]=[CH:13][C:14]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[CH:17]=[CH:16][CH:15]=2)[NH:3]1.[NH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH:28]([CH2:32][NH2:33])[CH2:27]1>C(O)C>[NH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][CH:28]([CH2:32][NH:33][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH:12]=[CH:13][C:14]3[C:23]4[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=4)[CH:17]=[CH:16][CH:15]=3)[N:3]=2)[CH2:27]1

参加物

4

反応物 2

HCID 174061,3-Bis(aminomethyl)cyclohexaneHCID 1784783434-Chloro-2-(2-naphthalen-1-yl-vinyl)-3,4-dihydro-quinazoline

生成物 1

HCID 68681390(3-Aminomethyl-cyclohexylmethyl)-[2-(2-naphthalen-1-yl-vinyl)-quinazolin-4-yl]-amine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-Chloro-2-(2-naphthalen-1-yl-vinyl)-3,4-dihydro-quinazoline (0.08 mmol), C-(3-aminomethyl-cyclohexyl)-methylamine (0.24 mmol) and 2 ml ethyl alcohol are placed in an 8 ml glass vial sealed with a teflon-lined screw cap. The mixture is heated at 80° for 3 hrs. After cooling to rt, the ethyl alcohol is removed. Ethyl acetate (3 ml) and water (3 ml) are added to the vial. After agitation, the water was removed. The procedure is repeated with water and aq. NaCl (sat.). Purification with silica gel afforded (3-aminomethyl-cyclohexylmethyl)-[2-(2-naphthalen-1-yl-vinyl)-quinazolin-4-yl]-amine;

後処理

  1. customcap
  2. temperatureThe mixture is heated at 80° for 3 hrs
  3. customthe ethyl alcohol is removed
  4. additionEthyl acetate (3 ml) and water (3 ml) are added to the vial
  5. customAfter agitation, the water was removed
  6. customPurification with silica gel

出典と根拠

ORDレコード
ord-3e196e30367a4ea7a3fb9a80d5c0c842
出典データセット
uspto-grants-2010_11
特許番号
US07829566B2

関連ノート

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