Piperazin-2-one → 3-Fluoro-N-{4-[3-(3-oxo-piperazin-1-yl)-propoxy]-naphthalen-1-yl}-5-piperidin-1-yl-benzamide

関与物質

反応手順

Compound is prepared from N-[4-(3-chloropropoxy)-naphthalen-1-yl]-3-fluoro-5-piperidin-1-yl-benzamide and 2-piperazinone according to conditions described in general procedure L. A white powder is produced (0.102 g, 60%). Mp: 90-92° C. 1H NMR (300 MHz, DMSO-d6) δ 10.23 (s, 1H), 8.24 (d, J=6.3 Hz, 1H), 7.86 (d, J=8.7 Hz, 1H), 7.75 (s, 1H), 7.56 (m, 2H), 7.45 (s, 1H), 7.42 (d, J=8.1, Hz, 1H), 7.16 (d, J=9.6 Hz, 1H), 7.01 (d, J=8.7 Hz, 1H), 6.93 (s, 1H), 4.22 (br s, 2H), 3.31 (m, 4H), 3.17 (br s, 2H), 2.98 (s, 2H), 2.61 (m, 4H), 2.06 (m, 2H), 1.60 (brs, 6H). MS: 505.2 (M+1).

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