Diisobutylaluminum hydride → 4-Iodo-2-propoxybenzenemethanol
反応式
[I:1][C:2]1[CH:11]=[CH:10][C:5]([C:6](OC)=[O:7])=[C:4]([O:12][CH2:13][CH2:14][CH3:15])[CH:3]=1.CC(C[AlH]CC(C)C)C>C1(C)C=CC=CC=1>[I:1][C:2]1[CH:11]=[CH:10][C:5]([CH2:6][OH:7])=[C:4]([O:12][CH2:13][CH2:14][CH3:15])[CH:3]=1参加物
4
実験手順
The procedure is the same as that described above, using 14 g of methyl 4-iodo-2-propoxybenzoate, 450 ml of toluene and 87.5 ml of DiBAlH. The product is purified by chromatography on a silica column, eluted with a heptane/ethyl acetate 9:1 mixture. After evaporation of the solvents, 11.3 g (88%) of the expected compound are recovered in the form of a yellow oil.
後処理
- customThe product is purified by chromatography on a silica column
- washeluted with a heptane/ethyl acetate 9:1 mixture
- customAfter evaporation of the solvents, 11.3 g (88%) of the expected compound
- customare recovered in the form of a yellow oil
出典と根拠
- ORDレコード
- ord-363731b29f9f4cd48a499b819f310336
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07829588B2
反応ノート
読み込み中…