Hydrogen Peroxide → 2-tert-Butyl-1-oxo-1lambda~5~-pyridinato

HRID 1171470ノート

反応式

HRID 1171470 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>CC(O)=O.C(Cl)Cl>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N+:6]=1[O-:11])([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 2

HCID 784Hydrogen PeroxideHCID 1386302-tert-Butylpyridine

生成物 1

HCID 187150642-tert-Butyl-1-oxo-1lambda~5~-pyridinato収率 71.5%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 6344Dichloromethane溶媒

実験手順

2-tert-Butylpyridine (2.00 g, 14.8 mmol, 1 eq.) was dissolved in HOAc (10 mL) and 30% hydrogen peroxide (1.68 mL, 14.8 mmol, 1 eq.) at room temperature then the reaction was refluxed for 20 hours. The reaction was stripped to obtain an amber oil which was dissolved in methylene chloride (10 mL) then dried over sodium sulfate and stripped to obtain 2-tert-butylpyridine-N-oxide (1.60 g) as an amber oil. Yield=71.5%. LCMS detects (M+H)+=152.09.

後処理

  1. customto obtain an amber oil which
  2. dry with materialthen dried over sodium sulfate

出典と根拠

ORDレコード
ord-1c1295db44b94ab1905e4e7a81a7d94f
出典データセット
uspto-grants-2010_11
特許番号
US07829571B2

反応ノート

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