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Benzyl Alcohol → 1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 2-benzylquinuclidin-3-yl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Alcohol | HCID 244 | — |
| 反応物 | 3-Quinuclidinol, (-)- | HCID 91404 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | benzyl (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylate | HCID 67078747 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 2-benzylquinuclidin-3-yl ester | HCID 67079110 | 173.5% |
反応手順
In a mixture of sodium benzyl alkoxide prepared from 0.19 g of benzyl alcohol and 0.04 g of metallic sodium with 15 ml of toluene and 0.75 ml of DMF, 1.33 g of (R)-quinuclidin-3-ol was allowed to react with 3.00 g of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid benzyl ester for 8 hours while evaporating the solvents, thereby obtaining 1.38 g of 1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 2-benzylquinuclidin-3-yl ester (to be referred to as “compound F” hereinafter).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07829715B2 |
| 出典データセット | uspto-grants-2010_11 |
| ORD ID | ord-a4adb67befd146c3ae8495e14908e573 |
| 出典メモ | uspto-grants-2010_11 |