Ethanol → Solifenacin Succinate

関与物質

反応条件

反応手順

A 6 ml portion of EtOH, 14 ml of EtOAc and 1.30 g of succinic acid were added to the thus obtained (1RS)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid (3R)-quinuclidin-3-yl ester, dissolved by heating and cooled to 50° C., and then 0.003 g of seed crystal of solifenacin succinate produced in the same manner as in Example 1A was added thereto. This mixture was cooled to 30° C., and then again heated to 50° C. This was kept at 50° C. for 2 hours and then cooled to 0° C. spending 5 hours, and the precipitated crystals were collected by filtration, washed twice with 10 ml of EtOAc and then dried under a reduced pressure to obtain 2.855 g of solifenacin succinate as colorless crystals.

情報源と証拠