Ethanol → HCID 86245030、化合物
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([OH:14])=[O:13].S(=O)(=O)(O)O.[CH2:20](O)[CH3:21]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[CH2:11][C:12]([O:14][CH2:20][CH3:21])=[O:13]参加物
4
実験手順
A mixture composed of 5.21 g (20 mmol) of (2-bromo-5-nitrophenyl)acetic acid (Zhumal Organicheskoi Khimii (1974) 10, 92-5), 80 ml of absolute ethanol and 0.1 ml of concentrated sulfuric acid is refluxed for 6 hours. After cooling, the reaction medium is concentrated under vacuum and taken up in ether. This organic phase is washed with saturated NaHCO3 solution and then with water, after which it is dried over Na2SO4. After concentrating under vacuum, 5.54 g of a beige solid are obtained.
後処理
- temperatureis refluxed for 6 hours
- temperatureAfter cooling
- concentrationthe reaction medium is concentrated under vacuum
- washThis organic phase is washed with saturated NaHCO3 solution
- dry with materialwith water, after which it is dried over Na2SO4
- concentrationAfter concentrating under vacuum, 5.54 g of a beige solid
- customare obtained
出典と根拠
- ORDレコード
- ord-a0acd240f22f4725a8b2ef91f5abc032
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07829721B2
反応ノート
読み込み中…