Hydrochloric Acid → HCID 178479673、化合物

HRID 1172445ノート

反応式

HRID 1172445 の反応式
[F:1][C:2]1[C:28]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5].[ClH:33]>C(O)C>[ClH:33].[F:1][C:2]1[C:28]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 178519567HCID 178519567、化合物

生成物 1

HCID 178479673HCID 178479673、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

19.8 g of 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine (Example 44) was suspended in 200 ml of ethanol, and aqueous hydrogen chloride solution (1.0 M, 44.1 ml) was added thereto. The reaction mixture was stirred at room temperature for 1 hour and then evaporated. The resulting residue was solidified with 200 ml of heptane, evaporated and dried to give 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine hydrochloride.

後処理

  1. customevaporated
  2. customevaporated
  3. customdried

出典と根拠

ORDレコード
ord-ad21d87a46894380a0a7b606a88b1a1a
出典データセット
uspto-grants-2010_11
特許番号
US07834018B2

反応ノート

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