1,4-Dioxane hydrochloride → 1-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

HRID 1172447ノート

反応式

HRID 1172447 の反応式
[Cl:1][C:2]1[C:3]([F:23])=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([N:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)=[O:6].Cl.O1CCOCC1>CO>[ClH:1].[Cl:1][C:2]1[C:3]([F:23])=[C:4]([CH:20]=[CH:21][CH:22]=1)[C:5]([N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)=[O:6]

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 57562582Tert-butyl 4-(3-chloro-2-fluorobenzoyl)piperazine-1-carboxylate

生成物 1

HCID 686779601-(3-Chloro-2-fluorobenzoyl)piperazine hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a mixture of 35.1 g of tert-butyl 4-(3-chloro-2-fluorobenzoyl)piperazine-1-carboxylate and 50 ml of methanol was added a hydrochloric acid-1,4-dioxane solution (4 M, 100 ml) followed by stirring at room temperature for 2.5 hours. The reaction mixture was concentrated in vacuo and the residue was suspended in diethyl ether, filtered and collected to give the title compound.

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. filtrationfiltered
  3. customcollected

出典と根拠

ORDレコード
ord-53a6ea84fea047dd91abeb6846450255
出典データセット
uspto-grants-2010_11
特許番号
US07834018B2

反応ノート

読み込み中…