関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Butyl vinyl ether | HCID 8108 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1,3-Bis(diphenylphosphino)propane | HCID 81219 | — |
| 反応物 | 4-(4-Chlorophenoxy)-2-propylphenyl trifluoromethanesulfonate | HCID 57420139 | — |
| 触媒 | palladium(II) acetate | HCID 167845 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-[4-(4-Chlorophenoxy)-2-propylphenyl]ethanone | HCID 57420140 | — |
反応手順
A mixture of the product from Step 6 (2.0 g, 5.0 mmol), n-butyl vinyl ether (25 mmol), triethylamine (0.83 mL, 6.0 mmol), palladium acetate (0.125 mmol) and 1,3-bis(diphenylphosphino)propane (51.5 mg, 0.125 mmol) in DMF (25 mL) was heated at 80° C. under nitrogen for 4 h. The reaction mixture was poured into 1 N hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with water and concentrated. The residue was purified by chromatography on silica gel to afford the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07834036B2 |
|---|
| 出典データセット | uspto-grants-2010_11 |
|---|
| ORD ID | ord-63abfcd3df294a0d9084bf9e7ce43386 |
|---|
| 出典メモ | uspto-grants-2010_11 |
|---|
