Bromine → 2-Bromo-1-[4-(4-chlorophenoxy)-2-propylphenyl]ethanone

HRID 1172812

反応式

HRID 1172812 の反応式
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([C:13](=[O:15])[CH3:14])=[C:9]([CH2:16][CH2:17][CH3:18])[CH:8]=2)=[CH:4][CH:3]=1.[Br:21]Br>O1CCOCC1.C(OCC)(=O)C>[Br:21][CH2:14][C:13]([C:10]1[CH:11]=[CH:12][C:7]([O:6][C:5]2[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][CH:4]=2)=[CH:8][C:9]=1[CH2:16][CH2:17][CH3:18])=[O:15]

参加物

5

反応物 2

HCID 24408BromineHCID 574201401-[4-(4-Chlorophenoxy)-2-propylphenyl]ethanone

生成物 1

HCID 574201412-Bromo-1-[4-(4-chlorophenoxy)-2-propylphenyl]ethanone

試薬・触媒・溶媒 2

HCID 8857Ethyl Acetate溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of the product from Step 7 (1.2 g, 4.2 mmol) in dioxane (20 mL) at room temperature was added dropwise bromine (0.25 mL, 5.0 mmol). After 2 h at room temperature, the reaction mixture was diluted with ethyl acetate, washed with an aqueous solution of sodium thiosulfate and dried over magnesium sulfate. Removal of the solvent gave a residue which was purified by chromatography on silica gel to give the title product.

後処理

  1. washwashed with an aqueous solution of sodium thiosulfate
  2. dry with materialdried over magnesium sulfate
  3. customRemoval of the solvent
  4. customgave a residue which
  5. customwas purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-4a0aca9f0f9142fd82b0edbabff23fc3
出典データセット
uspto-grants-2010_11
特許番号
US07834036B2

関連ノート

読み込み中…