4-Methoxyphenol → 1-[4-(4-Chlorophenoxy)-2-propylphenyl]-2-(4-methoxyphenoxy)ethanone

HRID 1172813

反応式

HRID 1172813 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[CH:7][C:6]=1[CH2:19][CH2:20][CH3:21])=[O:4].[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.C(OCC)(=O)C>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][O:30][C:27]3[CH:28]=[CH:29][C:24]([O:23][CH3:22])=[CH:25][CH:26]=3)=[C:6]([CH2:19][CH2:20][CH3:21])[CH:7]=2)=[CH:13][CH:14]=1

参加物

6

反応物 3

HCID 90154-MethoxyphenolHCID 10796Cesium carbonateHCID 574201412-Bromo-1-[4-(4-chlorophenoxy)-2-propylphenyl]ethanone

生成物 1

HCID 686927541-[4-(4-Chlorophenoxy)-2-propylphenyl]-2-(4-methoxyphenoxy)ethanone

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of the product from Step 8 (0.50 g, 1.4 mmol), p-methoxyphenol (2.8 mmol) and cesium carbonate (0.91 g, 2.8 mmol) in DMF (10 mL) was stirred at room temperature for 1 h. The reaction mixture was diluted with ethyl acetate and washed with water. The solvent was evaporated and the residue was purified by chromatography on silica gel to give the title product as an oil.

後処理

  1. washwashed with water
  2. customThe solvent was evaporated
  3. customthe residue was purified by chromatography on silica gel

出典と根拠

ORDレコード
ord-d0b2a8c484c34129829722107e95272c
出典データセット
uspto-grants-2010_11
特許番号
US07834036B2

関連ノート

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