Hydroxylamine → HCID 178458441、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH:11]([CH3:13])[CH3:12])[C:5]#[N:6].[NH2:14][OH:15]>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[O:10][CH:11]([CH3:13])[CH3:12])[C:5]([NH:14][OH:15])=[NH:6]参加物
4
反応条件
- 温度
- 60 °C
実験手順
Into a round bottom flask was added 3-chloro-4-isopropoxy-benzonitrile (5.00 g, 25.6 mmol), hydroxylamine (50% by weight in water, 1.86 mL, 28.1 mmol) and ethanol (150 mL). The mixture was heated at about 60° C. overnight. Upon completion of the reaction, the mixture was concentrated to dryness under reduced pressure to give 3-chloro-N-hydroxy-4-isopropoxy-benzamidine (5.76 g, 94%) as a light yellow solid.
後処理
- customUpon completion of the reaction
- concentrationthe mixture was concentrated to dryness under reduced pressure
出典と根拠
- ORDレコード
- ord-9ac6e34e096d415285a50f8a23ebdfab
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834039B2
反応ノート
読み込み中…