Ammonia → 1,6-Naphthyridin-2-amine

HRID 1173123ノート

反応式

HRID 1173123 の反応式
Cl[C:2]1[C:11]2[C:6](=C[C:8]([NH:12]S(C3C=CC(C)=CC=3)(=O)=O)=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[NH3:23]>>[NH2:23][C:8]1[CH:9]=[CH:10][C:11]2[C:6](=[CH:5][CH:4]=[N:3][CH:2]=2)[N:12]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 22674092HCID 22674092、化合物

生成物 1

HCID 5893531,6-Naphthyridin-2-amine収率 89.73%

実験手順

2-Chloro-1,6-naphthyridine (0.628 g, Production Example 22b) and an aqueous ammonia (40 ml) were heated at 130° C. for 11 hours in a sealed tube. After cooling, the mixture was extracted with ethyl acetate, and the extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated and the residue was purified by silica gel column, to give the title compound (0.497 g, 89.73%) as pale yellow crystals.

後処理

  1. temperatureAfter cooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washthe extract was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated
  6. customthe residue was purified by silica gel column

出典と根拠

ORDレコード
ord-b492d7e909e84a3b8aeb98ec74f19799
出典データセット
uspto-grants-2010_11
特許番号
US07834049B2

反応ノート

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