4-Iodobenzenesulfonyl chloride → HCID 22674075、化合物

HRID 1173143ノート

反応式

HRID 1173143 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([O:12][CH3:13])=[N:7][CH:6]=[CH:5]2.I[C:15]1[CH:20]=[CH:19][C:18]([S:21](Cl)(=[O:23])=[O:22])=[CH:17][CH:16]=1.C([Sn](CCCC)(CCCC)[C:30]1[S:31][CH:32]=[CH:33][N:34]=1)CCC>C1(C)C=CC=CC=1.C1C=CC([P]([Pd]([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)([P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[P](C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>[CH3:13][O:12][C:8]1[C:9]2[C:4](=[CH:3][C:2]([NH:1][S:21]([C:18]3[CH:19]=[CH:20][C:15]([C:30]4[S:31][CH:32]=[CH:33][N:34]=4)=[CH:16][CH:17]=3)(=[O:23])=[O:22])=[CH:11][CH:10]=2)[CH:5]=[CH:6][N:7]=1

参加物

6

反応物 3

HCID 73994-Iodobenzenesulfonyl chlorideHCID 27632592-(Tributylstannyl)-1,3-thiazoleHCID 226740451-Methoxyisoquinolin-6-amine

生成物 1

HCID 22674075HCID 22674075、化合物

試薬・触媒・溶媒 2

HCID 178418397HCID 178418397、化合物触媒HCID 1140Toluene溶媒

実験手順

The compound (40 mg) obtained using 6-amino-1-methoxyisoquinoline (Production Example 43b) and 4-iodobenzenesulfonyl chloride in the same method as in Synthetic Example 1b, 2-tri-n-butylstannylthiazole (136 mg) and tetrakis(triphenylphosphine)palladium (0) (11 mg) were heated under reflux for one hour in toluene in a nitrogen atmosphere. After evaporating the solvent, the residue was purified by silica gel column. The resulting crystals were recrystallized from methanol, to give the title compound (20 mg).

後処理

  1. temperaturewere heated
  2. customAfter evaporating the solvent
  3. customthe residue was purified by silica gel column
  4. customThe resulting crystals were recrystallized from methanol

出典と根拠

ORDレコード
ord-7760b20f743043ccb1e5c3dc8c6ec991
出典データセット
uspto-grants-2010_11
特許番号
US07834049B2

反応ノート

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