5-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile → 5-(1-Hydroxy-4-oxocyclohexyl)pyridine-2-carbonitrile

反応式

[OH:1][C:2]1([C:12]2[CH:13]=[CH:14][C:15]([C:18]#[N:19])=[N:16][CH:17]=2)[CH2:11][CH2:10][C:5]2(OCC[O:6]2)[CH2:4][CH2:3]1.OC1(C2C=CC(C#N)=CC=2)CCC(=O)CC1>>[OH:1][C:2]1([C:12]2[CH:13]=[CH:14][C:15]([C:18]#[N:19])=[N:16][CH:17]=2)[CH2:11][CH2:10][C:5](=[O:6])[CH2:4][CH2:3]1

参加物

反応物 2

HCID 667870965-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile

HCID 667872294-(1-Hydroxy-4-oxocyclohexyl)benzonitrile

生成物 1

HCID 667873885-(1-Hydroxy-4-oxocyclohexyl)pyridine-2-carbonitrile

実験手順

The title compound was synthesized from 5-(8-hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)pyridine-2-carbonitrile using the same typical deprotection procedure as for 4-(1-hydroxy-4-oxocyclohexyl)benzonitrile.

出典と根拠

ORDレコード: ord-9240919ed7e94cdb906a2229bd723545
出典データセット: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07834021B2

反応ノート

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