Hydrochloric Acid → 2-(Aminomethyl)-3,5-bis(trichlorovinyl)phenol
反応式
Cl.ClCC([NH:6][CH2:7][C:8]1[C:13]([C:14]([Cl:18])=[C:15]([Cl:17])[Cl:16])=[CH:12][C:11]([C:19]([Cl:23])=[C:20]([Cl:22])[Cl:21])=[CH:10][C:9]=1[OH:24])=O>C(O)C>[NH2:6][CH2:7][C:8]1[C:13]([C:14]([Cl:18])=[C:15]([Cl:17])[Cl:16])=[CH:12][C:11]([C:19]([Cl:23])=[C:20]([Cl:21])[Cl:22])=[CH:10][C:9]=1[OH:24]参加物
4
反応条件
- 温度
- 85 °C
実験手順
To a solution of 0.2 mL ethanol and 60 μL conc. hydrochloric acid was added 0.025 g (0.05 mmol) of the product of Step E and the reaction mixture was stirred and heated to 85° C. using an external oil bath overnight. The reaction mixture was then cooled to room temperature and evaporated in vacuo. The residue was triturated with ether and dried overnight in vacuo to afford the title compound as a white crystalline solid.