Hydrochloric Acid → HCID 10241702、化合物
反応式
[C:1]([C:5]1[CH:16]=[C:15]([CH3:17])[C:8]([CH2:9][NH:10]C(=O)CCl)=[C:7]([OH:18])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl>C(O)C>[NH2:10][CH2:9][C:8]1[C:15]([CH3:17])=[CH:16][C:5]([C:1]([CH3:3])([CH3:2])[CH3:4])=[CH:6][C:7]=1[OH:18]参加物
4
実験手順
To 0.2 g of N-(4-tert-butyl-2-hydroxy-6-methylbenzyl)-2-chloroacetamide from Step A in 10 mL of 95% ethanol was added 1 mL HCl. The resulting mixture was refluxed for 4 h then aged overnight at 50° C. The reaction mixture was concentrated to remove the ethanol and then partitioned between EtOAc and saturated aqueous NaHCO3. The organic layer was dried (Na2SO4), filtered and evaporated to afford the title compound.
後処理
- temperatureThe resulting mixture was refluxed for 4 h
- customaged overnight
- customat 50° C
- concentrationThe reaction mixture was concentrated
- customto remove the ethanol
- custompartitioned between EtOAc and saturated aqueous NaHCO3
- dry with materialThe organic layer was dried (Na2SO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-6a0d631a3f8f4b8eb556aace071b2b12
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834062B2
反応ノート
読み込み中…