Ethanol → HCID 11819299、化合物

HRID 1173765ノート

反応式

HRID 1173765 の反応式
Cl[CH:2]([CH:8]([OH:12])[CH2:9][CH2:10][CH3:11])[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(O)C.[O-]CC.[Na+].C(O)C>CCCCCC>[CH2:9]([C@@H:8]1[O:12][C@H:2]1[C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH2:10][CH3:11]

参加物

5

反応物 3

HCID 702EthanolHCID 22298443HCID 22298443、化合物HCID 23706232Ethanol sodium ethoxide

生成物 1

HCID 11819299HCID 11819299、化合物収率 87%

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Ethyl 2-chloro-3-hydroxyhexanoate synthesized in Example 9 (0.8 g, 4 mmol), ethanol (3 ml) and 20% sodium ethoxide/ethanol solution (1.52 g, 1.1 equivalents) were mixed, and the mixture was stirred at room temperature for 30 minutes. Hexane (10 ml) was added, and the mixture was washed with water (10 ml×twice). After the mixture was dried with anhydrous magnesium sulfate, the inorganic salt was separated by filtration. The filtrate was concentrated under reduced pressure. The title compound was obtained as a colorless oil (0.9 g, yield: 87%, (2R,3S) was the main ingredient).

後処理

  1. washthe mixture was washed with water (10 ml×twice)
  2. dry with materialAfter the mixture was dried with anhydrous magnesium sulfate
  3. customthe inorganic salt was separated by filtration
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-6471f42b52b3415e8e1c15bc4123de96
出典データセット
uspto-grants-2010_11
特許番号
US07834190B2

反応ノート

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