Acetone → (2S,3S)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride
反応式
C1(N[C:5]([C@H:7]2[O:11]C(C(C)C)=[N:9][C@H:8]2[CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:6])CC1.[ClH:22].CC(C)=[O:25]>>[ClH:22].[OH:11][C@@H:7]([C@@H:8]([NH2:9])[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:5]([OH:6])=[O:25]参加物
4
反応条件
- 温度
- 50 °C
実験手順
(4S,5S)—N-Cyclopropyl-2-isopropyl-4-benzyl-4,5-dihydro-1,3-oxazole-5-carboxamide (63 mg), acetone (2.5 ml) and concentrated hydrochloric acid (0.25 g) were mixed, and the mixture was stirred at 50° C. for 23 hours. The reaction mixture was concentrated, and isopropanol (5 ml) was added. The mixture was concentrated under reduced pressure. The same operation was further repeated, and then isopropanol (3 ml) was added to precipitate a crystal. The crystal was collected by filtration under reduced pressure, and was dried in vacuum to obtain the title compound as a white crystal (23 mg, yield: 36%).
後処理
- concentrationThe reaction mixture was concentrated
- additionisopropanol (5 ml) was added
- concentrationThe mixture was concentrated under reduced pressure
- additionisopropanol (3 ml) was added
- customto precipitate a crystal
- filtrationThe crystal was collected by filtration under reduced pressure
- customwas dried in vacuum
出典と根拠
- ORDレコード
- ord-6435a0b5d3874dec88944226e293c0e2
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834190B2
反応ノート
読み込み中…