2-Phthalimidomethyl-6-(3-dipropylaminopropyl)naphthalene → 2-Aminomethyl-6-(3-dipropylaminopropyl)naphthalene

HRID 1173993ノート

反応式

HRID 1173993 の反応式
C1(=O)[N:5]([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])[CH:13]=3)[CH:8]=2)C(=O)C2=CC=CC=C12>CN.CO>[NH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][N:20]([CH2:24][CH2:25][CH3:26])[CH2:21][CH2:22][CH3:23])[CH:13]=2)[CH:8]=1

参加物

3

反応物 1

HCID 230792442-Phthalimidomethyl-6-(3-dipropylaminopropyl)naphthalene

生成物 1

HCID 230792162-Aminomethyl-6-(3-dipropylaminopropyl)naphthalene収率 92.6%

試薬・触媒・溶媒 1

HCID 57454252Monomethylamine methanol溶媒

実験手順

The compound (439 mg) obtained in Example 121-10 was dissolved in a 40% methylamine/methanol solution (45 ml) and stirred at room temperature for 3 days. After completion of the reaction, the solvent was distilled off. Then, a 1 mol/l sodium hydroxide aqueous solution was added to the residue, and the whole was stirred. The solution was extracted with chloroform and the extract was washed with saturated saline solution. After that, the organic layer was dried with anhydrous sodium sulfate. Then, the solvent was distilled off, thereby obtaining the subject compound (283 mg) as a colorless oily substance.

後処理

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. additionThen, a 1 mol/l sodium hydroxide aqueous solution was added to the residue
  4. stirringthe whole was stirred
  5. extractionThe solution was extracted with chloroform
  6. washthe extract was washed with saturated saline solution
  7. dry with materialAfter that, the organic layer was dried with anhydrous sodium sulfate
  8. distillationThen, the solvent was distilled off

出典と根拠

ORDレコード
ord-6c4e3cfa13304a7eb2326acbc48a4991
出典データセット
uspto-grants-2010_11
特許番号
US07833991B2

反応ノート

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