1,4-Dioxane hydrochloride → 4-aminomethyl-N-(4-dipropylaminomethylphenyl)benzamide
反応式
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:31])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][N:24]([CH2:28][CH2:29][CH3:30])[CH2:25][CH2:26][CH3:27])=[CH:19][CH:18]=2)=[CH:11][CH:10]=1)(C)(C)C.Cl.O1CCOCC1>CO>[NH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][N:24]([CH2:28][CH2:29][CH3:30])[CH2:25][CH2:26][CH3:27])=[CH:19][CH:18]=2)=[O:31])=[CH:13][CH:14]=1参加物
4
実験手順
The compound (1.38 g) obtained in Example 122-2 was dissolved in methanol (10 ml), added with a 4 mol/l hydrogen chloride/dioxane solution (15 ml), and stirred at room temperature for 30 minutes. The reaction solution was concentrated under reduced pressure and neutralized with an anion-exchange resin (Amberlite IRA-410). The solvent was concentrated under reduced pressure and the residue was dried under vacuum, thereby obtaining the subject compound (0.79 g) as a yellow solid.