2-Phthalimidomethyl-6-(4-dipropylaminobutyl)naphthalene → 2-Aminomethyl-6-(4-dipropylaminobutyl)naphthalene

HRID 1174005

反応式

HRID 1174005 の反応式
C1(=O)[N:5]([CH2:6][C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:25][CH2:26][CH3:27])[CH2:22][CH2:23][CH3:24])[CH:13]=3)[CH:8]=2)C(=O)C2=CC=CC=C12>CN.CO>[NH2:5][CH2:6][C:7]1[CH:16]=[CH:15][C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:17][CH2:18][CH2:19][CH2:20][N:21]([CH2:25][CH2:26][CH3:27])[CH2:22][CH2:23][CH3:24])[CH:13]=2)[CH:8]=1

参加物

3

反応物 1

HCID 210843922-Phthalimidomethyl-6-(4-dipropylaminobutyl)naphthalene

生成物 1

HCID 210843902-Aminomethyl-6-(4-dipropylaminobutyl)naphthalene収率 127.5%

試薬・触媒・溶媒 1

HCID 57454252Monomethylamine methanol溶媒

実験手順

The compound (75.0 mg) obtained in Example 124-3 was dissolved in a 40% methylamine/methanol solution (2.0 ml) and stirred overnight at room temperature. After completion of the reaction, the solvent was distilled off and then the residue was added with a 1 mol/l sodium hydroxide aqueous solution and stirred. The solution was subjected to extraction with chloroform and the extract was then washed with saturated saline solution. Subsequently, the organic layer was dried with anhydrous sodium sulfate and the solvent was then distilled off, thereby obtaining the subject compound (67.5 mg) as a colorless oily substance.

後処理

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off
  3. additionthe residue was added with a 1 mol/l sodium hydroxide aqueous solution
  4. stirringstirred
  5. extractionThe solution was subjected to extraction with chloroform
  6. washthe extract was then washed with saturated saline solution
  7. dry with materialSubsequently, the organic layer was dried with anhydrous sodium sulfate
  8. distillationthe solvent was then distilled off

出典と根拠

ORDレコード
ord-9c7e9fee8f374433950539a7e56d776f
出典データセット
uspto-grants-2010_11
特許番号
US07833991B2

関連ノート

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