2-[2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-ylmethyl]isoindole-1,3-dione → [4-(6-aminomethyl-1-propyl-1H-benzimidazol-2-yl)butyl]dipropylamine

HRID 1174012ノート

反応式

HRID 1174012 の反応式
[CH2:1]([N:4]([CH2:33][CH2:34][CH3:35])[CH2:5][CH2:6][CH2:7][CH2:8][C:9]1[N:10]([CH2:30][CH2:31][CH3:32])[C:11]2[CH:17]=[C:16]([CH2:18][N:19]3C(=O)C4C(=CC=CC=4)C3=O)[CH:15]=[CH:14][C:12]=2[N:13]=1)[CH2:2][CH3:3]>CN.CO>[NH2:19][CH2:18][C:16]1[CH:15]=[CH:14][C:12]2[N:13]=[C:9]([CH2:8][CH2:7][CH2:6][CH2:5][N:4]([CH2:1][CH2:2][CH3:3])[CH2:33][CH2:34][CH3:35])[N:10]([CH2:30][CH2:31][CH3:32])[C:11]=2[CH:17]=1

参加物

3

反応物 1

HCID 231555012-[2-(4-dipropylaminobutyl)-3-propyl-3H-benzimidazol-5-ylmethyl]isoindole-1,3-dione

生成物 1

HCID 23079304[4-(6-aminomethyl-1-propyl-1H-benzimidazol-2-yl)butyl]dipropylamine収率 103.5%

試薬・触媒・溶媒 1

HCID 57454252Monomethylamine methanol溶媒

実験手順

The compound (173 mg) obtained in Example 125-5 was dissolved in a 40% methylamine/methanol solution (1.8 ml) and stirred at room temperature for 17 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and the residue was then purified through silica gel column chromatography (chloroform/ethyl acetate), thereby obtaining the subject compound (130 mg) as a pale-yellow viscous substance.

後処理

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure
  3. customthe residue was then purified through silica gel column chromatography (chloroform/ethyl acetate)

出典と根拠

ORDレコード
ord-a265f4f67a294f5087b76dd0108644c5
出典データセット
uspto-grants-2010_11
特許番号
US07833991B2

反応ノート

読み込み中…