1-Methylpyrrolidine → 1-(Methoxymethyl)-1-methylpyrrolidin-1-ium bromide
反応式
[CH3:1][N:2]1[CH2:6][CH2:5][CH2:4][CH2:3]1.[CH3:7][O:8][CH2:9][Br:10]>CC(C)=O.O>[Br-:10].[CH3:7][O:8][CH2:9][N+:2]1([CH3:1])[CH2:6][CH2:5][CH2:4][CH2:3]1参加物
5
反応条件
- 温度
- 15 °C
実験手順
A 17.0 g quantity of N-methylpyrrolidine was dissolved in 160 g of dehydrated acetone (up to 0.1% in water content), followed by nitrogen replacement. To the solution was added dropwise 24.6 g of bromomethyl methyl ether (reagent, product of Tokyo Kasei Co., Ltd.) at 5° C. over a period of 1.5 hours. The mixture was stirred at 5 to not higher than 15° C. for 4 hours to terminate the reaction. The reaction mixture was filtered, and the resulting solids were washed with 160 g of acetone, and dried in a vacuum, affording 30.9 g of the desired product (white solid).
後処理
- customto terminate
- customthe reaction
- filtrationThe reaction mixture was filtered
- washthe resulting solids were washed with 160 g of acetone
- customdried in a vacuum
出典と根拠
- ORDレコード
- ord-d84364220cfa4c0ea714dd4573354c86
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834197B2
反応ノート
読み込み中…