Sulfuric acid magnesium salt (1:1) → Ethyl 2-(methoxymethyl)-1,3-thiazole-4-carboxylate
反応式
[CH3:1][O:2][CH2:3][C:4](=[S:6])[NH2:5].Br[CH2:8][C:9](=O)[C:10]([O:12][CH2:13][CH3:14])=[O:11].S([O-])([O-])(=O)=O.[Mg+2]>CC(C)=O>[CH3:1][O:2][CH2:3][C:4]1[S:6][CH:8]=[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[N:5]=1参加物
5
反応条件
- 温度
- 25 °C
実験手順
A solution containing the product from Example 6B (7 g, 66.6 mmol) in acetone (270 mL) was treated with ethyl bromopyruvate (8.4 mL, 66.6 mmol) and magnesium sulfate (7.9 g, 66.6 mmol), heated at reflux for 16 hours, cooled to 25° C., filtered and concentrated. The residue was chromatographed on silica gel eluting with chloroform to give the title compound (7.6 g, 57% yield).
後処理
- temperatureheated
- temperatureat reflux for 16 hours
- filtrationfiltered
- concentrationconcentrated
- customThe residue was chromatographed on silica gel eluting with chloroform
出典と根拠
- ORDレコード
- ord-c309c551cafd42dfad164da8f90a272b
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07834043B2
反応ノート
読み込み中…