Pivalaldehyde → 2,2-Dimethyl-5-hexen-3-ol

HRID 1174314ノート

反応式

HRID 1174314 の反応式
[CH3:1][C:2]([CH3:6])([CH3:5])[CH:3]=[O:4].[CH2:7]([Mg]Br)[CH:8]=[CH2:9]>C(OCC)C>[CH3:1][C:2]([CH3:6])([CH:3]([OH:4])[CH2:9][CH:8]=[CH2:7])[CH3:5]

参加物

4

反応物 2

HCID 12417PivalaldehydeHCID 178455850HCID 178455850、化合物

生成物 1

HCID 1405562,2-Dimethyl-5-hexen-3-ol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

A solution of trimethylacetaldehyde (10.2 mL, 90.9 mmol) in diethyl ether (200 mL) at 0° C. was treated with allylmagnesium bromide (100 mL, 1 M in ether), stirred at 0° C. for 1 hour, quenched with saturated ammonium chloride and extracted with diethyl ether. The organic phase was washed with brine and dried over Na2SO4, filtered and concentrated to give the title compound (11.6 g).

後処理

  1. customquenched with saturated ammonium chloride
  2. extractionextracted with diethyl ether
  3. washThe organic phase was washed with brine
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-b43ebccd1ac24905b74a717053e46356
出典データセット
uspto-grants-2010_11
特許番号
US07834043B2

反応ノート

読み込み中…