Acetone → Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-

HRID 1174369ノート

反応式

HRID 1174369 の反応式
[CH3:1][C@H:2]([CH2:6]SC)[C:3]([OH:5])=[O:4].O[O:10][S:11]([O-:13])=O.[K+].[CH3:15]C(C)=O>O>[CH3:1][C@H:2]([CH2:6][S:11]([CH3:15])(=[O:13])=[O:10])[C:3]([OH:5])=[O:4]

参加物

5

反応物 3

HCID 180AcetoneHCID 23707502Potassium hydroxy sulfiteHCID 51669008HCID 51669008、化合物

生成物 1

HCID 15814191Propanoic acid, 2-methyl-3-(methylsulfonyl)-, (S)-収率 45%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
25 °C

実験手順

A solution of Example 149A (0.085 g, 0.63 mmol) in acetone (1.2 mL) and water (0.25 mL) at 0° C. was treated with oxone (1.17 g, 1.9 mmol) and the mixture was stirred at 25° C. for 3 h. The mixture was filtered, rinsed with acetone, and the solvents were evaporated. The residue was dissolved in ethyl acetate, dried over MgSO4, filtered and the solvents were evaporated to give the crude title compound (47 mg, 45%).

後処理

  1. filtrationThe mixture was filtered
  2. washrinsed with acetone
  3. customthe solvents were evaporated
  4. dissolutionThe residue was dissolved in ethyl acetate
  5. dry with materialdried over MgSO4
  6. filtrationfiltered
  7. customthe solvents were evaporated

出典と根拠

ORDレコード
ord-01c3497e07fd4911b953457185c6a005
出典データセット
uspto-grants-2010_11
特許番号
US07834043B2

反応ノート

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