tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate → (S)-3,3-Dimethyl-2-(methylsulfonamido)butanoic acid

反応式

[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([O:11]C(C)(C)C)=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]>Cl.O1CCOCC1>[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([OH:11])=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]

参加物

実験手順

A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).

後処理

customthe solvents were evaporated

出典と根拠

ORDレコード: ord-b2894561c7914198ba750d8652d40cbb
出典データセット: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07834043B2

反応ノート

読み込み中…

参加物

反応物 1

HCID 86599586tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate

生成物 1

HCID 61142133(S)-3,3-Dimethyl-2-(methylsulfonamido)butanoic acid収率 106.4%

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒

HCID 312751,4-Dioxane溶媒

実験手順

A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).

後処理

customthe solvents were evaporated

出典と根拠

ORDレコード: ord-b2894561c7914198ba750d8652d40cbb
出典データセット: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07834043B2

反応ノート

読み込み中…