Hydrochloric Acid → 4-Chloro-5-methyl-6-(piperidin-4-ylsulfanyl)-pyrimidine
反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([S:14][C:15]2[C:20]([CH3:21])=[C:19]([Cl:22])[N:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>O1CCOCC1>[Cl:22][C:19]1[C:20]([CH3:21])=[C:15]([S:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[N:16]=[CH:17][N:18]=1参加物
4
実験手順
A mixture of 4-(6-chloro-5-methyl-pyrimidin-4-ylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester (2.3469 g, 6.82 mmol) and 40 mL of 4M HCl in dioxane was stirred at room temperature over night. Mixture was concentrated to give 4-chloro-5-methyl-6-(piperidin-4-ylsulfanyl)-pyrimidine as a yellowish solid (1.8985 g, 99%). Exact mass calculated for C10H14ClN3S 243.06, found 244.1 (MH+).
後処理
- concentrationMixture was concentrated
出典と根拠
- ORDレコード
- ord-3b0321b088b64095a2e1bbebc01edd88
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07838525B2
反応ノート
読み込み中…