(3,4-Dichlorophenoxy)acetic acid → 2-(3,4-Dichloro-phenoxy)-N-[2-(3-dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-yl]-acetamide
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[Cl:13])[O:5][CH2:6][C:7]([OH:9])=O.[CH3:14][N:15]([CH3:31])[CH:16]1[CH2:20][CH2:19][N:18]([C:21]2[S:22][C:23]3[CH:29]=[C:28]([NH2:30])[CH:27]=[CH:26][C:24]=3[N:25]=2)[CH2:17]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[Cl:13])[O:5][CH2:6][C:7]([NH:30][C:28]1[CH:27]=[CH:26][C:24]2[N:25]=[C:21]([N:18]3[CH2:19][CH2:20][CH:16]([N:15]([CH3:31])[CH3:14])[CH2:17]3)[S:22][C:23]=2[CH:29]=1)=[O:9]参加物
3
実験手順
Prepare according to the procedures described in Example 1, step 4, Method B, using 3,4-dichlorophenoxyacetic acid (135 mg, 0.611 mmol) and 2-(3-dimethylamino-pyrrolidin-1-yl)-benzothiazol-6-ylamine (162 mg, 0.618 mmol) to afford the title compound, mass spectrum (m/e): 465 [M+H], 463 [M−H].
後処理
- customPrepare