Morpholine → HCID 59558570、化合物

HRID 1175175ノート

反応式

HRID 1175175 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10]Br)=[C:6]([CH:9]=1)[C:7]#[N:8].[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]([CH:9]=1)[C:7]#[N:8]

参加物

5

反応物 3

HCID 8083MorpholineHCID 11430Potassium CarbonateHCID 442031405-Bromo-2-(bromomethyl)benzonitrile

生成物 1

HCID 59558570HCID 59558570、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of 5-bromo-2-bromomethyl-benzonitrile (2.0 g, 7.3 mmol), morpholine (0.76 g, 8.7 mmol) and K2CO3 (1.0 g, 7.3 mmol) is stirred in 50 DMF at room temperature for 72 hours. The reaction mixture is filtered and the filtrate is dried under vacuum to yield the title compound. 1H-NMR (400 MHz; DMSO-d6): 8.11 (d, 1H), 7.90 (dd, 1H), 7.53 (d, 1H), 3.60 (s, 2H), 3.56 (t, 4H), 2.39 (t, 4H). LC-MS (m/z, ES+): 281 (MH+), Retention time: 1.79 mins (LC-MS method 2)

後処理

  1. filtrationThe reaction mixture is filtered
  2. customthe filtrate is dried under vacuum

出典と根拠

ORDレコード
ord-fe4dbb7167dd4f5d96a578502b9e6d6c
出典データセット
uspto-grants-2010_11
特許番号
US07838674B2

反応ノート

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