2-Amino-1-butanol → (S)-2-(4-(6-cyanopyrazin-2-yl)phenyl)-N-(1-hydroxybutan-2-yl)-2-methylpropanamide

反応式

[C:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([CH3:20])([CH3:19])[C:16]([OH:18])=O)=[CH:11][CH:10]=2)[CH:6]=[N:5][CH:4]=1)#[N:2].[NH2:21][CH:22]([CH2:25][CH3:26])[CH2:23][OH:24]>>[C:1]([C:3]1[N:8]=[C:7]([C:9]2[CH:10]=[CH:11][C:12]([C:15]([CH3:20])([CH3:19])[C:16]([NH:21][C@@H:22]([CH2:25][CH3:26])[CH2:23][OH:24])=[O:18])=[CH:13][CH:14]=2)[CH:6]=[N:5][CH:4]=1)#[N:2]

参加物

反応物 2

HCID 221292-Amino-1-butanol

HCID 687764432-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid

生成物 1

HCID 68774850(S)-2-(4-(6-cyanopyrazin-2-yl)phenyl)-N-(1-hydroxybutan-2-yl)-2-methylpropanamide収率 37%

実験手順

Prepared in a similar manner to Example 20 from 2-(4-(6-Cyanopyrazin-2-yl)phenyl)-2-methylpropanoic acid (example 20a) and 2-aminobutan-1-ol. Yield 37%.

出典と根拠

ORDレコード: ord-fb89cedf3bb84586ab9f2be8d1a0c51d
出典データセット: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07842324B2

反応ノート

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