1-Chloro-4-methoxybutane → tert-Butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-{[(4-methoxybutyl)phenyl-carbamoyl]methoxy}piperidine-1-carboxylate
反応式
[CH3:1][O:2][C:3]1[CH:44]=[CH:43][CH:42]=[CH:41][C:4]=1[CH2:5][O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]2[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:18]2[O:30][CH2:31][C:32](=[O:40])[NH:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[CH:13][CH:12]=1.Cl[CH2:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51]>>[CH3:1][O:2][C:3]1[CH:44]=[CH:43][CH:42]=[CH:41][C:4]=1[CH2:5][O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[CH:12]=[CH:13][C:14]([CH:17]2[CH2:22][CH2:21][N:20]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[CH2:19][CH:18]2[O:30][CH2:31][C:32](=[O:40])[N:33]([CH2:46][CH2:47][CH2:48][CH2:49][O:50][CH3:51])[C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)=[CH:15][CH:16]=1参加物
3
実験手順
Analogously to Example 2c, 0.49 g of tert-butyl 4-{4-[3-(2-methoxybenzyloxy)propoxy]phenyl}-3-phenylcarbamoylmethoxypiperidine-1-carboxylate (Example 62b) and 0.37 g of 1-chloro-4-methoxybutane are reacted. The title compound is obtained as a yellow oil. Rf=0.20 (1:1 EtOAc-heptane); Rt=5.89.
出典と根拠
- ORDレコード
- ord-b07c9aaaed3c464897cfdbc99eb52409
- 出典データセット
- uspto-grants-2010_11