Methylamine → 4-(2-hydroxyphenyl)-N-methylbutyramide

HRID 1176398ノート

反応式

HRID 1176398 の反応式
[O:1]1[C:7](=[O:8])[CH2:6][CH2:5][CH2:4][C:3]2[CH:9]=[CH:10][CH:11]=[CH:12][C:2]1=2.[CH3:13][NH2:14]>C(O)(C)C>[OH:1][C:2]1[CH:12]=[CH:11][CH:10]=[CH:9][C:3]=1[CH2:4][CH2:5][CH2:6][C:7]([NH:14][CH3:13])=[O:8]

参加物

4

反応物 2

HCID 6329MethylamineHCID 109757954,5-Dihydrobenzo[b]oxepin-2(3H)-one

生成物 1

HCID 685011294-(2-hydroxyphenyl)-N-methylbutyramide

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A solution of 1.0 g of 4,5-dihydro-3H-benzo[b]oxepin-2-one and 40 ml of 10% methylamine in isopropanol is heated in an autoclave at 100° C. over 16 hours. The reaction mixture is cooled to room temperature and concentrated by evaporation. The title compound is obtained as white crystals from the residue by means of flash chromatography (SiO2 60F). Rf=0.20 (4:1 EtOAc-heptane); Rt=2.66.

後処理

  1. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-46c0c9a46292460a8488aa84ee483bde
出典データセット
uspto-grants-2010_11
特許番号
US07842688B2

反応ノート

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