2-Ethylbutyryl chloride → HCID 72326551、化合物
反応式
[CH2:1]([CH:3]([CH2:7][CH3:8])[C:4](Cl)=[O:5])[CH3:2].[CH2:9]([O:11][C:12](=[O:16])[CH2:13][C:14]#[N:15])[CH3:10].[Na]>C(OCC)C>[C:14]([C:13](=[C:4]([OH:5])[CH:3]([CH2:7][CH3:8])[CH2:1][CH3:2])[C:12]([O:11][CH2:9][CH3:10])=[O:16])#[N:15]参加物
4
反応条件
- 温度
- 25 °C
実験手順
At 0° C., 74 g (0.55 mol) of 2-ethylbutyryl chloride were added dropwise to a suspension of 150 g (1.1 mol) of sodium cyanoacetate ethyl ester in diethyl ether. The reaction mixture was stirred at 25° C. for 16 h and then hydrolyzed, and the organic phase was separated off. The aqueous phase was washed with ether and then acidified to pH 3. The enol released in this manner was extracted, washed and dried. Customary purification gave 81 g (70% of theory) of the title compound as a viscous colorless liquid (b.p. 78 to 81° C./1.2 mbar).